Revised EU endocrine disruptors proposal draws fresh criticism from scientists

November 17, 2016 at 1:41 pm | Posted in Feature Articles | Leave a comment

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A group of 15 scientists researching endocrine disruption, risk assessment methods and environmental chemistry have written a new open letter to European Commission President Jean-Claude Juncker and Health and Food Safety Commissioner Vytenis Andriukaitis.

The letter asks for a wide range of changes to be made to the Commission’s proposals for regulatory identification of endocrine disruptors, arguing that procedures as currently outlined prohibit “full and fair use of the existing evidence” and “[do] not capture best practice in evidence synthesis and integration”.

The letter, which can be read here, is not the only recent response by scientists criticizing the Commission’s proposed criteria for identification of endocrine disruptors.

A commentary in Environmental Health Perspectives argued why potency should not be considered when identifying endocrine hazards (a proposal which now seems to be off the table, at least for the time being), and the Endocrine Society issued a critical press release, citing “unnecessarily narrow criteria for identifying EDCs that will make it nearly impossible for scientists to meet the unrealistically high burden of proof and protect the public from dangerous chemicals”.

November 2016 News Bulletin: TSCA brings in new era of US chemical risk management; 40% of UK councils exceed air pollution limits

November 17, 2016 at 12:28 pm | Posted in Uncategorized | Leave a comment

November 2016 News Bulletin

TSCA 2.0: A New Era in Chemical Risk Management. Early indicators suggest the new law will more effectively protect people—including vulnerable populations such as children and pregnant women—than the old law it replaces. But stakeholders are watching closely to see if the changes really do live up to their promise. (EHP)

EU drops law to limit cancer-linked chemical in food after industry complaint. Campaigners say leaked documents show ‘undue influence’ by the food industry after plans to limit acrylamide – found in starchy foods such as crisps, cereals and baby foods – are weakened. (The Guardian)

Reducing Developmental Neurotoxin Exposure. Citing an alarming increase in childhood neurodevelopmental disorders such as autism and attention-deficit/hyperactivity disorder (ADHD), a group of scientists, health professionals, and children’s health advocates is calling for increased monitoring, assessment, and reduction of neurotoxic chemicals. The Targeting Environmental Neuro-Developmental Risks (TENDR) Consensus Statement, published in July in Environmental Health Perspectives, is “a call to action to reduce exposures to toxic chemicals that can contribute to the prevalence of neurodevelopmental disabilities in America’s children.” (JAMA)

Four in 10 UK councils exceed air pollution limits, figures show. Ministers reveal 169 local authorities breached annual legal limits on nitrogen oxide, linked to lung disease, last year. (The Guardian)

Fragranced products: Risks for people and profits? New research has found that over one-third of Americans report health problems when exposed to common fragranced consumer products, and that fragranced products may affect profits, with more than 20% of respondents entering a business, but leaving as quickly as possible if they smell air fresheners or some fragranced product. (Eurekalert)

New research report on flame retardant chemicals shows Canada’s failure to protect health. A new report by a coalition of Canadian researchers highlights the failure of federal regulations to keep harmful flame retardant chemicals out of homes and consumer products. Toxic by Design, released today by the Endocrine Disruptors Action Group (EDAction), investigates how flaws in Canada’s regulatory approach to toxic flame retardants have far-reaching health effects. (Morningstar.com)

November 2016 Science Bulletin: BPA, obesity and fast food consumption; air pollutants slow mental development

November 17, 2016 at 12:07 pm | Posted in News and Science Bulletins | Leave a comment

November 2016 Science Bulletin

BPA, obesity | Bisphenol A and Adiposity in an Inner-City Birth Cohort. Analyses of the CCCEH longitudinal birth cohort found associations between prenatal urinary BPA concentrations and FMI, %BF, and WC. Our results suggest that prenatal BPA exposure may contribute to developmental origins of adiposity. These findings are consistent with several prior studies, raising concern about the pervasiveness of BPA.

BPA and phthalates, exposure | Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003-2010. We observed evidence of a positive, dose-response relationship between fast food intake and exposure to phthalates (p-trend < 0.0001) but not BPA; participants with high consumption (≥ 34.9% TEI from fast food) had 23.8% (95% CI: 11.9%, 36.9%) and 39.0% (95% CI: 21.9%, 58.5%) higher levels of ΣDEHPm and DiNPm, respectively, than nonconsumers. Fast food-derived fat intake was also positively associated with ΣDEHPm and DiNPm (p-trend < 0.0001). After adjusting for other food groups, ΣDEHPm was associated with grain and other intake, and DiNPm was associated with meat and grain intake.

Air pollution, hampered neurodevelopment | Neurodevelopmental Deceleration by Urban Fine Particles from Different Emission Sources: A Longitudinal Observational Study. An interquartile range increase in indoor traffic-related PM2.5 was associated with reductions in cognitive growth equivalent to 22% (95% CI: 2%, 42%) of the annual change in working memory, 30% (95% CI: 6%, 54%) of the annual change in superior working memory, and 11% (95% CI: 0%, 22%) of the annual change in the inattentiveness scale. None of the other PM2.5 sources was associated with adverse effects on cognitive development.

EDC exposure reduction | Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study. This study demonstrates that techniques available to consumers, such as choosing personal care products that are labeled to be free of phthalates, parabens, triclosan, and BP-3, can reduce personal exposure to possible endocrine-disrupting chemicals. Involving youth in the design and implementation of the study was key to recruitment, retention, compliance, and acceptability of the intervention.

EDCs, obesity | Metabolism Disrupting Chemicals and Metabolic Disorders. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome.

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